Ubiquinol for Healthy Ageing: How Ubiquinol Supports Energy, Vitality and Wellbeing Across All Life Stages 

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Discover how Kaneka Ubiquinol™ supports mitochondrial health and cellular energy to promote healthy ageing, naturally.

Healthy ageing isn’t just about living longer, it’s about maintaining energy, clarity and strength to enjoy those years fully. At the cellular level, one nutrient plays a vital role in this process: Ubiquinol, the active form of coenzyme Q10 (coQ10).

Naturally found in every cell of the body, Ubiquinol plays two essential roles: it fuels the mitochondria to produce over 90% of the body’s energy (in the form of ATP),[1] and it helps reduce free radicals formed in the body, protecting cells from oxidative stress. These actions are especially important in high-energy organs like the heart, brain and muscle.

But as we age, our ability to produce and maintain Ubiquinol levels decreases.[2,3] By age 80, concentrations in the heart may be up to 50% lower than in early adulthood.[2,4,5] Lifestyle factors such as stress, poor diet, certain medications, and exposure to oxidative stress can also contribute to Ubiquinol depletion.[6-8]

Why Healthy Mitochondrial Function Matters

Kaneka Ubiquinol™ plays a central role in maintaining mitochondrial efficiency, which is pivotal to ageing well. When mitochondrial efficiency declines, so does our ability to generate energy, repair tissues and recover from daily stressors.

Ubiquinol supports ATP production, reduces oxidative stress and helps stabilise cell membranes, all of which protect against the physiological wear and tear associated with ageing.

This mitochondrial support benefits the entire body:

  • Energy and fatigue relief: Ubiquinol helps maintain physical endurance and relieve tiredness and fatigue, particularly during periods of increased stress, reduced sleep or chronic illness.[9-12]
  • Heart and cardiovascular support: The heart requires enormous energy to function. Ubiquinol supports cardiovascular health, maintains healthy blood vessels and cholesterol levels, [13-16] and helps offset the depletion that may be caused by cholesterol-lowering medications.[17-19]
  • Cognitive health and focus: In clinical studies, 100 mg of Ubiquinol daily over 34 weeks improved memory, attentiveness and information processing in middle-aged and older adults.[20]
  • Reproductive support: Ubiquinol plays a role in fertility by supporting healthy egg and sperm quality, helping maintain reproductive health later in life.[21-23] It also supports mood, energy and general wellbeing in women experiencing menopause.[24,25]
  • Muscle function and exercise recovery: Ubiquinol helps reduce exercise-induced oxidative stress, supports faster muscle recovery, and improves stamina and strength,[26-29] all of which are important for maintaining mobility and independence as we age.
  • General wellbeing: By protecting against cellular inflammation and preserving mitochondrial integrity, Ubiquinol supports all body systems and overall systemic health.[30-33]

Kaneka Ubiquinol™: Backed by Research, Made for Bioavailability

Kaneka Ubiquinol™ is the only patented, bioidentical form of uUbiquinol manufactured using a precision yeast fermentation process. It is:

  • Clinically researched with over 100 studies and 45+ years of data
  • Directly usable by the body without the need for conversion
  • Highly absorbable—up to 8x more bioavailable than the oxidised ubiquinone form of CoQ10 [34-36]
  • Trusted by premium supplement brands worldwide

For individuals with reduced ability to convert ubiquinone, such as older adults or those under increased oxidative stress, Kaneka Ubiquinol™ offers direct, efficient support for energy and cellular function.

Cellular Health for a Longer Healthspan

Healthy ageing isn’t just about living more years; it’s about making those years count. Ubiquinol supports the foundations of vitality by fuelling mitochondria, protecting cells and supporting key systems involved in energy, heart health, cognition, muscle function and reproduction.

Whether you’re managing midlife energy dips, supporting recovery from illness, staying active into your 70s, or simply wanting to age well, Kaneka Ubiquinol™ is a trusted, natural solution for whole-body support.

For Brandholders and Healthcare Practitioners

Kaneka Ubiquinol™ is ideally suited for active ageing and longevity-focused supplements, especially in the areas of:

  • Energy and vitality
  • Cardiovascular health and cholesterol maintenance
  • Cognitive health
  • Muscle function and performance
  • Male and female fertility
  • General health and wellbeing in ageing individuals

Download our Healthy Ageing Fact Sheet, via the Science Hub for clinical summaries, system-specific benefits and dosing guidelines for your brand or clinical practice.

Always read the label and follow the directions for use. Consult your healthcare professional to establish if Ubiquinol is suitable for your needs. 

 

References: 

  1. Decker ST, Funai K. Mitochondrial membrane lipids in the regulation of bioenergetic flux. Cell Metab 2024;36(9):1963-1978.
  2. Kalén A, et al. Age-related changes in the lipid compositions of rat and human tissues. Lipids 1989;24(7):579-584.
  3. Wada H, et al. Redox status of coenzyme Q10 is associated with chronological age. JAGS. 2007;55:1141-1142.
  4. Fernández-Ayala DJM, et al. Invertebrate models for coenzyme q10 deficiency. Mol Syndromol 2014;5(3-4):170-179.
  5. Okamoto T, et al, Human serum ubiquinol-10 levels and relationship to serum lipids. Int J Vitam Nutr Res 1989;59(3):288-292.
  6. Varela-Lopez A, et al. Coenzyme Q and its role in the dietary therapy against aging. Molecules 2016;21(3):373.
  7. Kontush A, et al. Plasma ubiquinol-10 as a marker for disease: Is the assay worthwhile? BioFactors 1999;9(2-4):225-229.
  8. Soni A, et al. Coenzyme Q10 therapy in current clinical practice. Intern J Res Med Sci 2015;3(4):817.
  9. Mizuno K, et al. Ubiquinol-10 intake is effective in relieving mild fatigue in healthy individuals. Nutrients 2020;12(6):1640.
  10. Fukuda S, et al. Ubiquinol-10 supplementation improves autonomic nervous function and cognitive function in chronic fatigue syndrome. Biofactors 2016;42(4):431-440.
  11. Morikawa H, et al. Reduced form of coenzyme Q10 relieves daily life stress and improves sleep quality in healthy subjects with high stress sensitivity-a randomized, double-blind, parallel-group study. Jpn Pharmacol Ther 2019;57(8):1231-1244.
  12. Kawaharada Y, Toyomasu K. Usefulness of regular intake of the reduced form of CoQ10 for stress management for workers. Jpn Pharmacol Ther 2013; 41:1129-1137.
  13. Pérez-Sánchez C, et al. Ubiquinol effects on antiphospholipid syndrome prothrombotic profile: A randomized, placebo-controlled trial. Arterioscler Thromb Vasc Biol 2017;37(10):1923-1932.
  14. Sabbatinelli J, et al. Ubiquinol ameliorates endothelial dysfunction in subjects with mild-to-moderate dyslipidemia: A randomized clinical trial. Nutrients 2020;12(4):1098.
  15. Onur S, et al. Association between serum level of ubiquinol and NT-proBNP, a marker for chronic heart failure, in healthy elderly subjects. Biofactors 2015;41(1):35-43.
  16. Kawashima C, et al. Ubiquinol improves endothelial function in patients with heart failure with reduced ejection fraction: A single-center, randomized double-blind placebo-controlled crossover pilot study. Am J Cardiovasc Drugs 2020;20(4):363-372.
  17. Zlatohlavek L, et al. The effect of coenzyme Q10 in statin myopathy. Neuro Endocrinol Lett 2012;33:98-101.
  18. Vaughan RA, et al. Ubiquinol rescues simvastatin-suppression of mitochondrial content, function and metabolism: implications for statin-induced rhabdomyolysis. Eur J Pharmacol 2013;711(1-3):1-9.
  19. Kloer HU, et al. Combining Ubiquinol with a statin may benefit hypercholesterolaemic patients with chronic heart failure. Heart Lung Circ 2020;29(2):188-195.
  20. Kinoshita T, et al. The effects of ubiquinol (reduced form of coenzyme Q10) on memory, attentiveness, and work processing ability in healthy middled-aged and elderly residents – A randomized, double-blind, placebo-controlled trial. Jpn Pharmacol Ther 2021;49:1739-1747.
  21. Derbyshire E (2024). CoQ10 Ubiquinol: The surfacing of science and role in female and male fertility. A narrative review. 10.20944/preprints202407.0879.v1.
  22. Thakur AS, et al. Effect of Ubiquinol on serum reproductive hormones of amenorrhic patients. Indian J Clin Biochem 2016;31(3):342-348.
  23. Thakur AS, et al. Effect of ubiquinol therapy on sperm parameters and serum testosterone levels in oligoasthenozoospermic infertile men. J Clin Diagn Res 2015;9(9):BC01-03.
  24. Palacios S, et al. The effectiveness of coenzyme Q-10 (Ubiquinol) on the quality of life in postmenopausal women. Toko-Gin Pract 2019;78(1):3-7.
  25. Ota M, et al. The effects of Ubiquinol intake and sociophysical training on the activation of psychological and infrared camera-measured body temperature physiology and blood molecular markers: A pilot study among healthy female older adults. Appl Sci 2024;14(6):2366.
  26. Moreno-Fernandez J, et al. Ubiquinol short-term supplementation prior to strenuous exercise improves physical performance and diminishes muscle damage. Antioxidants (Basel) 2023;12(6):1193.
  27. Suzuki Y, et al. Short-term ubiquinol-10 supplementation alleviates tissue damage in muscle and fatigue caused by strenuous exercise in male distance runners. Int J Vitam Nutr Res 2021;91(3-4):261-270.
  28. Sarmiento A, et al. Short-term Ubiquinol supplementation reduces oxidative stress associated with strenuous exercise in healthy adults: A randomized trial. Biofactors 2016;42(6):612-622.
  29. Kunching S, et al. The effects of ubiquinol supplementation on clinical parameters and physical performance of trained men. Songklanakarin J Sci Technol (SJST) 2022;44(1):231-235.
  30. Shoko D, et al. The effect of the reduced form of coenzyme Q10 (Ubiquinol, Kaneka QH™) on QoL improvement in the elderly. J Clin Therap Med 2008;24:233-238.
  31. Cirilli I, et al. Role of coenzyme Q10 in health and disease: An update on the last 10 years (2010–2020). Antioxidants 2021;10:1325.
  32. San-Millán I. The key role of mitochondrial function in health and disease. Antioxidants (Basel) 2023;12(4):782.
  33. Amorim JA, et al. Mitochondrial and metabolic dysfunction in ageing and age-related diseases. Nat Rev Endocrinol 2022;18(4):243-258.
  34. Failla M, et al. Increased bioavailability of ubiquinol compared to that of ubiquinone is due to more efficient micellarization during digestion and greater GSH-dependent uptake and basolateral secretion by caco-2 cells. J Agricult Food Chemistry 2014;62.
  35. Zhang Y, et al. Ubiquinol is superior to ubiquinone to enhance Coenzyme Q10 status in older men. Food Funct 2018;9(11):5653-5659.
  36. Hosoe K, et al. Study on safety and bioavailability of ubiquinol (Kaneka QH) after single and 4-week multiple oral administration to healthy volunteers. Regul Toxicol Pharmacol 2007;47:19-28.
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